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This research snapshot provides an overview of a SERN-funded project led by Mary Helen Immordino-Yang and Camille Farrington. This project was designed to leverage data collected from a longitudinal, cross-cultural project on the social-emotional brain development of adolescents from economically disadvantaged backgrounds. The researchers explored how students’ neurobiological predispositions in social-emotional processing interact with their learning environments (i.e., community and family) and cultural influences to shape their social functioning over time. The snapshot shares key findings, information on the interdisciplinary research team, and insights and future directions for the project.